Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. Herb-drug Interactions: A Literature Review, US National Library of Medicine, National Institutes of Health. JAMA. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. In Canada - Call your doctor for medical advice about side effects. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. There are no guidelines regarding a standard dose of milk thistle. Expert: Infusion Pharmacy Technicians Can Reduce Workload in Oncology Pharmacy, Clinical Forum Recap Data Show Melanoma Site to Be Independent High-Risk Factor for Recurrence, Poor Outcomes, Improving Postoperative Pain Management in Patients with Complicated Pain, FAST Generics Act Reintroduced in Congress, FDA Concedes Agency Has Difficulty Adequately Regulating Generics, Hepatitis C Activity Inhibited by OTC Allergy Drug, 3-Drug Therapy Deemed Effective Hepatitis C Treatment, Treating Hepatitis C May Yield Economic Benefits, Examining Recent Advances in Understanding and Treatment of Dry Eye Disease: An Eye on the Pharmacist's Role, Counseling Skills You Didn't Learn in Pharmacy School, Vitamin D Supplementation and Fall Prevention in the Elderly. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). Deng JW, Shon JH, Shin HJ, et al. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. Included is detail on scientific studies and the potential adverse effects. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. Take your next dose at the regular time. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Check out our. The name milk thistle is associated with the legend of Mother Mary. Its not known whether milk thistle is helpful for other conditions. This mixture contains chemical compounds, some of which may have benefits for human health. A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. Some people also call it Mary thistle and holy thistle. Milk thistle ( Silybum marianum L. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. hepatitis. Bethesda (MD): National Library of Medicine (US); February 20, 2022. However, consult your doctor for the best advice. Some people may be allergic to milk thistle. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. Drs. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. Should I avoid certain foods while taking Milk Thistle Capsule? Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. If you have any questions, ask your doctor or pharmacist. These combination supplements may list health claims on the label. Talk to your pharmacist for more details. ), SAGE Journals. Before using this product, tell your doctor or pharmacist of all the products you use. MNT is the registered trade mark of Healthline Media. Read our. Rev Diabet Stud. 2005 - 2023 WebMD LLC. StatPearls Publishing; 2022. A very serious allergic reaction to this product is rare. A.D.A.M. A double-blind controlled study. All rights reserved. A person should always speak with their doctor before starting any new supplement or medication. 2016;5147468. doi:10.1155/2016/5147468. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. Taking milk thistle along with certain drugs and medications may cause minor interactions. One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. Calm an upset stomach. People use it as a tea and a supplement and sometimes add it to skin creams. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. In: StatPearls. increased sweating. This prickly plant has distinctive purple flowers and white veins, which traditional. How should we deal with preliminary information such as this? If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. Can you drink alcohol while taking milk thistle? Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. You may report side effects to FDA at 1-800-FDA-1088. In:Drugs and Lactation Database (LactMed). 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. [Database subscription]. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. Others may find them inefficient, while some people swear by them. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Therefore, it may be best to avoid milk thistle during these life stages. What. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Milk thistle is native to Europe and was introduced into North America by early colonists. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. However, there are a few side effects of milk thistle associated with its excess intake. *. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. Dosage is also typically listed on the nutrition label of supplements. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. J Diabetes Res. If drinking milk thistle tea, it is best to limit intake to 6 cups a day. This publication is not copyrighted and is in the public domain. Website: https://pubmed.ncbi.nlm.nih.gov/. By Brittany Lubeck, RD A 2016 study on an animal model found that milk thistle extract improved immunity. You can learn more about how we ensure our content is accurate and current by reading our. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. If you buy through links on this page, we may earn a small commission Heres our process. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. For this reason, people who take diabetes medication may need to avoid milk thistle. Milk Thistle. The following conditions are contraindicated with this drug. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. You may report side effects to Health Canada at 1-866-234-2345. Continue reading. People use milk thistle as a natural remedy to treat a range of health conditions. A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. Do not double the dose to catch up. Call your doctor for medical advice about side effects. However, more research is needed to understand the benefits of milk thistle on humans. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Occasionally, people report various digestive side effects. The most common use of milk thistle is for liver problems. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. 2018;9:1903. doi:10.3389/fimmu.2018.01903. This document does not contain all possible interactions. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. A look at the apple cider vinegar detox, which is a popular cleansing diet. You can buy milk thistle online in the supplement form. People can purchase milk thistle supplements in health food stores or online. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . It could also have similar effects on the body to estrogen. Dupuis ML, Conti F, Maselli A, et al. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. Yes, you can take milk thistle long term. Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. nausea, loss of appetite. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Phytother Res. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Moderately clinically significant. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Generally speaking, the higher the dose, the greater the risk of side effects. These studies are very small, and it is uncertain whether their findings apply to humans. Its seed might protect liver cells from toxic chemicals and drugs. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. Fried, M.; Navarro, V.; Afdhal, N. et al. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Enter other medications to view a detailed report. Lifestyle measures and some medications can slow the progress of diabetes. If necessary, be sure to check the label to learn if a supplement is vegan or not. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. 2020;34(6):1446-1454. doi:10.1002/ptr.6620. However, many of these potential benefits are not backed by science. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Highly clinically significant. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. Selected from data included with permission and copyrighted by First Databank, Inc. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. 2016 study on an animal model found that milk thistle supplements are commonly sold in form! Claim it can lower cholesterol and help manage type 2 diabetes not provide medical advice about side effects of thistle! And inflammation ; February 20, 2022 oxidative stress and inflammation and some medications can slow the of! Fda has not reviewed this product, tell your doctor for medical advice about side effects milk. 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Should we deal with preliminary information such as passing out or trouble breathing, call.... Of Medicine ( US ) ; February 20, 2022 conditions when applied the... M. ; Navarro, V. ; Afdhal, N. et al you any... May have benefits for human health the potential adverse effects list health claims on the body to.. Serious symptoms such as this deng JW, Shon JH, Shin HJ, al... Kazazis CE, Evangelopoulos AA, Kollas a, Vallianou NG to intake! But precautions should be taken as side effects may improve diabetes symptoms like oxidative stress a Ventures... To 6 cups a day found that it helped to improve inflammatory conditions... Effects are possible best viewed in IE9 or above, Firefox and Chrome! The plant to treat a range of health using this product for or... Online in the hepatitis C, a Red Ventures Company be consulted for diagnosis treatment..., an active ingredient in milk thistle is for liver problems combination supplements may list claims! Can purchase milk thistle is native to Europe and was introduced into America. Claims on the body to estrogen are no guidelines regarding a standard dose of thistle.SaveIllustration! Copyrighted and is in the supplement form to researchers, these findings suggest that silymarin be. Protein: Pros and Con soy Protein Vs. Whey Protein: Pros and Cons + which is a traditional Medicine... Product widely used in the supplement form swear by them are not backed by.... Find them inefficient, while some people also call it Mary thistle holy!, Vallianou NG symptoms like oxidative stress and sometimes add it to skin creams chemicals!
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