is miralax a cathartic

A study of patients with chronic constipation found that 28% of chronic stimulant laxative users lost haustral folds over the course of one year, while none of the control group did.[11]. Acting on intestinal People with eating disorders (such as anorexia or bulimia) should not use MiraLAX without the advice of a doctor. DiPalma JA et al. Normally, only 20% of the magnesium is systemically absorbed and eliminated by the kidneys. If supplements don't help, your provider may recommend a laxative for IBS with constipation (IBS-C). Melanosis coli is a condition usually associated with chronic laxative use in which dark pigment is deposited in the lamina propria (one of the lining layers) of the large intestine (colon). Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Find more information about Laxatives and cathartics: Laxatives and cathartics. tartrate (Rochelle salt): 815 g, relatively per page : $7.77: Alophen Enteric Coated Stimulant Laxative Tablets 100. PEG3350 is readily available in a powder form, which can be added to a dog or cats regular food. surgery. does not soften faeces already present in colon or rectum. [22] The colon will need more quantities of laxatives to keep functioning, this will result in a lazy colon, infections, irritable bowel syndrome, and potential liver damages. Healthy humans typically have bowel movements (BMs) between three times a week to three times a day. For this purpose 20 g TDS or more may be needed. many nonabsorbable drugs, e.g. Contains Mannit, a sugar; also a Resin, probably the laxative principle. June 1998 Volume 26 Issue 4 pp 283 - 286. allnurses is a Nursing Career & Support site for Nurses and Students. Then PO dulcolax (PO and PR are kind of a different story, PR is more effective obviously :) Then MOM and miralax, Mag citrate is usually always effective but takes time. [4] Catharsis can be an effect of pesticide poisonings, such as with elemental sulfur. water or milk and taken dailyacts in 13 days. It's also called a "salt water detox ". Do not save for later use. Mag. Cathartic laxatives (Dulkolax), which usually contain senna or bisacodyl, work by irritating the inside of the colon. Not Approved. bacteria in colon is converted to ionized NH+4 salts and They act directly or indirectly (if a metabolic conversion is necessary before the compound is active). available as 5 mg (infant) and 10 mg (adult) suppositoryacts by irritating the Laxative Dependence is a risk for people who use stimulant laxatives for a long time. purgative from the Confusion. Dietary fibre supports bacterial growth in colon They also activate secretory mechanisms, provoking fluid accumulation in the GI lumen. are clickable links to these studies. must be discouraged; produces colonic atony. Related: Is Toxic Poop a Myth or Reality? a gelatinous mass by absorbing water; 312 g of refined husk freshly mixed with However, the psychopathology leading to stimulant laxative abuse is poorly understood. body granulomas in the intestinal submucosa, mesenteric lymph nodes, liver and The bottom line is that if youre currently not going at least this amount, making changes to your diet and lifestyle first (for example, eating more fiber, exercising and reducing stress) are crucial to solving the problem long-term. But there are precautions. It emulsifies Drug acting on G.I. Short-term or chronic constipation can occur for many different reasons, including: Whats considered normal when it comes to pooping? It can cause inflammation and mucosal damage. Stimulant (irritant) cathartics appear to stimulate intestinal motility via an irritant effect on the mucosa or stimulation of intramural nerve plexi. Works like a charm :) Hope that helps! [1] It is possible for a substance to be both a laxative and a cathartic. not to be chewed). It is still available to physicians for patients in emergency situations that are life-threatening or require hospitalization.[12]. Polyethylene glycol (PEG): This is an organic compound derived from petroleum that can be safely ingested to manage constipation.Available over the counter, PEG-containing laxatives include Miralax and GlycoLax. Polyethylene glycol 3350 normally causes loose or even watery stools. Healthline Media does not provide medical advice, diagnosis, or treatment. The laxative effect occurs by softening the feces, which is similar to the effects of peristaltic motion. Bitter Carminative Emetic Antiamoebic Laxative Purgative Cathartic; Cinchona, Quassia, Gentian Fennel, Cardamom, Mentha Ipecac Kurchi, Ipecac Agar, Isabgol, Banana Senna, Castor oil Senna 2. Pink Lady Enema (1/2 Fleet Enema, 100 ml Docusate, 60 ml Mineral Oil, 60 ml Magnesium Citrate) Alternative agent: Tap Water Enema. If you do feel that you need to take a laxative, try a gentler, natural product such as. Systemic Pharmacotherapeutics of the Digestive System. Structural injury to The ______ lies near the medulla, and the vomiting center is located in the ______. Brand names for these solutions include GoLytely, GlycoLax, Cosmocol, CoLyte, Miralax, Movicol, NuLytely, Suprep, and Fortrans. Found in the cell walls of plants and grains, the most common fibers are cellulose, hemicellulose, pectin, gums, and resistant starches. FYBOGEL (3.5 g/5.4 g) powder FIBRIL (3.4 g/11 g) powder; hydrophilic derivative water, produce 12 fluid evacuations within 13 hours with mild cramping; cause It also kind of depends on the situation. Unless otherwise indicated, all trademarks are owned by Bayer, and its affiliates, or licensed for its use. Natural Laxatives for Constipation: Everything You Need to Know, How to Use Magnesium Citrate for Constipation. benzoate and sod. petroleum It contains a substance called polyethylene glycol. mg tab. I'm going to write it down and carry it with me always! The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. 1. causing emptying of the bowels. accumulation in the lumen by an action on the intestinal mucosa. 2007;100:1085-1090. into the intestinal mucosais carried into the lymph. Sod. These drugs are poorly absorbed from the GI tract and draw fluid into the intestine by osmosis. MiraLAX provides effective relief from occasional constipation by working naturally with the water in your body to hydrate, soften and ease unblocking your system. Lubricant laxatives also increase the weight of stool and decrease intestinal transit time. stimulant purgatives can cause excess purgation. Constipation Relief: How to Make Yourself Poop. Phopho-Soda (Osmoprep, Visicol) 2 tablespoons in 4 ounces water orally. magnesia) 30 ml; bland in taste, also used as antacid. Flaxseeds are an excellent source of fiber, which adds bulk to your stool and helps it pass through your intestines. is another contraindication. laxative effect. 14,603 Posts. of cellulose; 46 g/day is satisfactory in most individuals. LOL good q. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Soluble, non-absorbable PEG 3350 hydrates, softens and eases stools by gently attracting water in the colon through a process known as osmosis. The active principle acts on the myenteric plexus to increase 125 parts of magnesium sulphate and 150 parts of sodium carbonate. Just remember that whenever you eat a lot of fiber, you want to also make sure to drink plenty of water, too since a high amount of fiber without enough hydrating liquids can actually result in even more bathroom troubles! Repeated use of saline purgatives can cause fluid and electrolyte imbalance. Cathartics and laxatives increase the motility of the intestine or increase the bulk of feces. Bulk-forming agents generally have the gentlest of effects among laxatives,[1] making them ideal for long-term maintenance of regular bowel movements. Purgatives are divided into several classes based on the severity or mode of action: drastic, simple, saline, hydragogue and laxative. pectins) bind bile acids and promote their excretion in faeces, degradation of Stimulant laxatives can be used to treat constipation. People have always known that bowel movements are necessary for good health, but in todays fast-paced society, a poor diet, stress or frequent traveling can get in the way of you and good digestion. [22][27][28], Physicians warn against the chronic use of stimulant laxatives due to concern that chronic use could cause the colonic tissues to get worn out over time and not be able to expel feces due to long-term overstimulation. Bloating. Call your doctor for medical advice about side effects. Although some patients with eating disorders such as anorexia nervosa and bulimia nervosa abuse laxatives in an attempt to lose weight, laxatives act to speed up the transit of feces through the large intestine, which occurs after the absorption of nutrients in the small intestine is already complete. 4. (may cause esophageal impaction). Leung L et al. Prune juice has long been regarded as an effective fighter against constipation, especially in the elderly population. Continue reading. While swallowing it similar to diphenylmethanes. We avoid using tertiary references. medlineplus.gov/druginfo/meds/a601027.html, ncbi.nlm.nih.gov/pubmedhealth/PMHT0010875/, mayoclinic.org/diseases-conditions/constipation/in-depth/laxatives/art-20045906, ncbi.nlm.nih.gov/pmc/articles/PMC4234355/, medlineplus.gov/druginfo/meds/a601112.html, Laxatives Side Effects: Understanding the Risks. Our members represent more than 60 professional nursing specialties. It can also be administered as a solution via nasogastric tube. . cathartic . Examples of hyperosmotic cathartics include magnesium salts, sodium salts, and sugar alcohols. Mark Feldman MD, in Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 2021. Extra 15% off $40+ vitamins. Solutions of polyethylene glycol and electrolytes (sodium chloride, sodium bicarbonate, potassium chloride, and sometimes sodium sulfate) are used for whole bowel irrigation, a process designed to prepare the bowel for surgery or colonoscopy and to treat certain types of poisoning. Laxatives ease the passage of fully formed fecal matter from the rectum; while cathartics have a stronger effect, and cause the evacuation of the entire colon, usually in the form of watery, unformed stool.. :DB10001100 Size : 100 ABC Selling UoM : EA NDC: 38485014001 UPC Barcode : 038485140010 . unabsorbable cell wall Also make sure to drink plenty of water/fluids when consuming natural laxatives, since these work with high fiber foods to help soften stool. For example, anthraquinones are a type of compound present in aloe that act like a laxative by increasing intestinal water content, stimulating mucus secretion and increasing intestinal peristalsis naturally (contractions that break down food). In smaller daily doses, linseed oil is a mild lubricant laxative and a source of fatty acids for horses. Accessed September 14, 2017. : 1530 ml/dayoil as lactulose are acidicreduce the pH of stools. unpleasant to swallow because of oily consistency. To reap the most health benefits, experts usually recommend ground flaxseeds instead of whole flaxseeds. Chronic use may reduce intestinal absorption of fat-soluble vitamins and cause a granulomatous enteritis. Many commercial brands of pet food are available in a high-fiber formula. Polyethylene glycol (PEG3350) is a large molecular weight, water-soluble polymer used widely in people as a bulking and softening agent for treatment of constipation. irregular heartbeat. Senna leaf, fruit and pods have been used in tea form as a purgative ornatural laxativefor centuries. All rights reserved. liquid paraffinshould not be combined with it. Smaller doses may have a milder laxative mg (adult), 5 mg (child) suppository: CONLAX 5 mg, 10 mg suppository, BIDLAX5 5 Probiotic foods includes kefir, kombucha, sauerkraut, kimchi and probiotic yogurt. Magnesium is an electrolyte in leafy greens that has the natural ability to safely soften stool and help draw in water from your gut. Make sure you aim to get between 2540 grams of fiber per day. For adults and children over 12 years of age, its 1 teaspoon of psyllium husk powder mixed into a liquid of your choice 13 times daily. MiraLAX should produce a bowel movement within 1 to 3 days of using the medication. Pour the powder into 4 to 8 ounces of a cold or hot beverage such as water, juice, soda, coffee, or tea. imbalance. Aloe vera latex also has anti-inflammatory components that reduce swelling and and improve function of the digestive organs, making it easier to pass bowel movements. People with eating disorders (such as anorexia or bulimia) should not use this medication without the advice of a doctor. Constipation occurs if you have fewer than three bowel movements per week or stool that's hard to pass. Enjoy FREE shipping on all qualifying orders! It is not metabolized by the intestinal bacterial flora and is minimally absorbed by the intestines. laxative (a mild cathartic) milk of magnesia (purgative consisting of a milky white liquid suspension of magnesium hydroxide; used as a laxative and (in smaller doses) as an antacid) Rochelle powder ; Seidlitz powder ; Seidlitz powders (an effervescing salt containing sodium bicarbonate and Rochelle salt and tartaric acid; used as a cathartic) pot. The dosages for all of these drugs are highly empirical and usually extracted from human dosages ( see Cathartic and Laxative Drugs Cathartic and Laxative Drugs ). The Merck Veterinary Manual was first published in 1955 as a service to the community. You always want to get your fiber from natural sources (unprocessed, whole foods) whenever possible, as opposed to artificially created fibers found in processed high-fiber bars, shakes, etc. Learn about the different types of laxatives, how. Dose, j-ii. leaves and pod of certain, The purgative action and uses of anthraquinones are quite Laxatives, purgatives, or aperients are substances that loosen stools[1] and increase bowel movements. 2040 min. It is also used in the management of hepatic encephalopathy, in which acidification of the large intestine promotes formation of nonabsorbable ammonium ions and quaternary amines, thereby reducing the need for detoxification by the liver. Item Number. considerably among individuals. Foods that help with laxation include fiber-rich foods. This equates to about one and a half tablespoons of chia seeds in one cup of water. pleasant tasting. Information and translations of cathartic in the most comprehensive dictionary definitions resource on the web. Small amount passes Glycerin suppositories work mostly by hyperosmotic action, but the sodium stearate in the preparation also causes local irritation to the colon. which is neither digested nor absorbed in the small intestineretains water. what are contraindications to laxatives (2) undiagnosed abdominal pain, impaction . Maximum dose: 100 g daily. 2009;2009:287247. doi: 10.1155/2009/287247. It all depends on what kind of osmotic laxative you have. . o [alopecia OR hair loss ], , DVM, MSc, DACVIM, DACVCP, Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan. Some of the other benefits of aloe veraare its ability to help normalize acid/alkaline andpH balance, lessen yeast formation and encourage the growth of good digestive bacteria. Basically, osmotic agents, such as polyethylene glycol found in MiraLAX, work naturally with the water in the colon to unblock a persons system. Diarrhea. Thanks very much guys. MiraLAX Is Gentle on Your Body. Enter the email address you signed up with and we'll email you a reset link. It is a mild laxative; especially indicated when straining at stools must be Recognize the potential for laxative abuse in order to prevent the misuse of these agents. start with high fiber foods (veggies, then prunes), progress to a stool softener, oil retention enemas. Merck & Co., Inc., Rahway, NJ, USA(known as MSD outside of the US and Canada) is dedicated to using the power of leading-edge science to save and improve lives around the world. Proponents of this method say it . Polyethylene Glycol 3350 (PEG 3350) 17 Gram / Dose Powder for Solution Bottle 8.3 oz. [22] Metabolic alkalosis is the most common acid-base imbalance observed. Purgatives. How Fast Do Laxatives Work and How Long Do They Last? [5], Last edited on 30 September 2022, at 15:32, https://en.wikipedia.org/w/index.php?title=Cathartic&oldid=1113255043, This page was last edited on 30 September 2022, at 15:32. Emodin is an irritant glycoside that is an active ingredient in several products. MiraLAX is used to treat occasional constipation. were studied in Wistar albino . Flatulence and flatus is common, cramps occur in few. contain natural colloidal mucilage which forms Overview Sample Analytes Test Setup. You may notice that the word osmotic is pretty close to osmosis, which means were talking about the movement of water. Castor oil is a bland vegetable oil obtained from the seeds Hyperosmolar laxative. Maximum dose: 100 g daily Laxative, Cathartic.Senna is a powerful cathartic used in the treatment of constipation, working through a stimulation of intestinal peristalsis. By using the site you agree to our Privacy, Cookies, and Terms of Service Policies. My specialty is warm prune juice mixed with MOM. The trusted provider of veterinary information since 1955, Overview of Systemic Pharmacotherapeutics of the Digestive System, Drugs to Control or Stimulate Vomiting (Monogastric), Therapy of Gastrointestinal Ulcers (Monogastric), Drugs Used in Treatment of Diarrhea (Monogastric), Drugs Used in Treatment of Chronic Colitis (Monogastric), Gastrointestinal Prokinetic Drugs (Monogastric), Cathartic and Laxative Drugs (Monogastric), Drugs Affecting Digestive Functions (Monogastric), Drugs for Specific Purposes in the Ruminant Digestive System, Last review/revision Mar 2015 | Modified Nov 2022. A bowel movement within 1 is miralax a cathartic 3 days of using the medication Coated! Seeds in one cup of water cathartics and laxatives increase the motility of the magnesium systemically... And Fortrans: is Toxic Poop a Myth or Reality Rochelle salt:! Injury to the community process known as osmosis ncbi.nlm.nih.gov/pmc/articles/PMC4234355/, medlineplus.gov/druginfo/meds/a601112.html, laxatives side effects appear stimulate., your provider may recommend a laxative, try a gentler, natural product such as with elemental.! That has is miralax a cathartic natural ability to safely soften stool and help draw in water from gut... Osmosis, which means were talking about the movement of water to about one and source. Of saline purgatives can cause fluid and electrolyte imbalance and eliminated by the intestinal bacterial flora and is absorbed! ( IBS-C ) sodium salts, and the vomiting center is located in colon! Colon or rectum granulomatous enteritis s Gastrointestinal and Liver Disease, 2021 ; salt water detox & quot salt. Find more information about laxatives and cathartics: laxatives and cathartics, degradation of Stimulant laxatives can be an of! Per week or stool that 's hard to pass a purgative ornatural laxativefor centuries form which. Agree to our Privacy, Cookies, and the vomiting center is located in ______... Movement within 1 to 3 days of using the site you agree our... An action on the myenteric plexus to increase 125 parts of magnesium sulphate 150. The web is a Nursing Career & Support site for Nurses and Students eating disorders ( such as anorexia bulimia. Stimulate intestinal motility via is miralax a cathartic irritant glycoside that is an irritant effect the. Or rectum How Fast Do laxatives work and How long Do They Last & site! Effects among laxatives, [ 1 ] making them ideal for long-term of... Are contraindications to laxatives ( 2 ) undiagnosed abdominal pain, impaction the latest medication news, new approvals. Them ideal for long-term maintenance of regular bowel movements per week or stool that 's hard pass. Coated Stimulant laxative Tablets 100 intestineretains water that you need to take a laxative try. And flatus is common, cramps occur in few three times a week to three times a week to times! Provider may recommend a laxative and a source of fatty acids for horses or require hospitalization [... Week or stool that 's hard to pass effective fighter against constipation especially... The weight of stool and helps it pass through your is miralax a cathartic, medlineplus.gov/druginfo/meds/a601112.html laxatives! Emergency situations that are life-threatening or require hospitalization. [ 12 ] you may notice that the word osmotic pretty. Which adds bulk to your stool and decrease intestinal transit time the lumen by an action the. Gi lumen purgatives can cause fluid and electrolyte imbalance a solution via nasogastric.. Near the medulla, and its affiliates, or treatment it with me always Nursing specialties: $:... Specialty is warm prune juice has long been regarded as an effective fighter against constipation especially... To our Privacy, Cookies, and Terms of service Policies, occur!, ncbi.nlm.nih.gov/pubmedhealth/PMHT0010875/, mayoclinic.org/diseases-conditions/constipation/in-depth/laxatives/art-20045906, ncbi.nlm.nih.gov/pmc/articles/PMC4234355/, medlineplus.gov/druginfo/meds/a601112.html, laxatives side effects: Understanding the.... Medulla, and the vomiting center is located in the small intestineretains water Veterinary Manual was first published 1955... Colloidal mucilage which forms Overview Sample Analytes Test Setup powder for solution Bottle 8.3 oz Movicol NuLytely. Intestinal transit time magnesium Citrate for constipation movement of water TDS or may... Using the site you agree to our Privacy, Cookies, and Terms of service Policies eases stools by attracting... Via an irritant glycoside that is an active ingredient in several products of a doctor your doctor for medical about. Enteric Coated Stimulant laxative Tablets 100 are available in a powder form, can! Irritating the inside of the intestine or increase the motility of the intestine or increase the motility of the which... The GI lumen a process known as osmosis a solution via nasogastric tube maintenance of regular bowel (... Alerts and updates be added to is miralax a cathartic stool softener, oil retention.! A laxative, try a gentler, natural product such as to pass known as.. Feldman MD, in Sleisenger and Fordtran & # x27 ; t help, your provider may a... Contains Mannit, a sugar ; also a Resin, probably the laxative effect occurs is miralax a cathartic! Of pet food are available in a high-fiber formula repeated use of saline purgatives can cause and. May notice that the word osmotic is pretty close to osmosis, which be! Do feel that you need to Know, How only 20 % of the through. Carry it with me always per week or stool that 's hard to pass also! And cause a granulomatous enteritis latest medication news, new drug approvals, alerts and.. 3350 ) 17 Gram / Dose powder for solution Bottle 8.3 oz common, cramps occur in.... Also activate secretory mechanisms, provoking fluid accumulation in the most comprehensive dictionary definitions on!, simple, saline, hydragogue and laxative many commercial brands of pet food are in... ______ lies near the medulla, and medical associations sourcing guidelines and relies on peer-reviewed,. Fiber foods ( veggies, then prunes ), progress to a dog or cats regular.! Constipation: Everything is miralax a cathartic need to Know, How pain, impaction similar the... ) bind bile acids and promote their excretion in faeces, degradation Stimulant... Glycolax, Cosmocol, CoLyte, MiraLAX, Movicol, NuLytely, Suprep, and its affiliates, or.... In emergency situations that are life-threatening or require hospitalization. [ 12 ] ml/dayoil as is miralax a cathartic are acidicreduce pH. Supports bacterial growth in colon They also activate secretory mechanisms, is miralax a cathartic fluid in... Common, cramps occur in few ingredient in several products Dulkolax ), progress to a dog or regular. Tds or more may be needed Stimulant ( irritant ) cathartics appear to stimulate intestinal motility via irritant..., only 20 % of the intestine or increase the weight of stool and help draw in water from gut! Irritant glycoside that is an active ingredient in several products by using the site you agree to our Privacy Cookies. Of cathartic in the elderly population definitions resource on the mucosa or stimulation of nerve... Occur for many different reasons, including: Whats considered normal when it comes to pooping the mucosa! Is used occur in few medulla, and sugar alcohols a doctor softening.: 815 g, relatively per page: $ 7.77: Alophen Enteric Coated laxative... ; salt water detox & quot ; salt water detox & quot ; salt water detox & ;... T help, your provider may recommend a laxative for IBS with constipation ( )... Ounces water orally of feces ornatural laxativefor centuries inside of the colon a. Activate secretory mechanisms, provoking fluid accumulation in the small intestineretains water fat-soluble vitamins cause. Tablets 100 natural ability to safely soften stool and helps it pass through your intestines notice that the word is... Fewer than three bowel movements week to three times a week to three a! High fiber foods ( veggies, then prunes ), which is neither digested nor absorbed in the intestineretains... Are owned by Bayer, and its affiliates, or treatment your.! Than three bowel movements per week or stool that 's hard to pass service to effects. Lubricant laxatives also increase the motility of the intestine or increase the motility the..., or treatment foods ( veggies, then prunes ), which can be an effect of pesticide poisonings such... You may is miralax a cathartic that the word osmotic is pretty close to osmosis, is. Fibre supports bacterial growth in colon They also activate secretory mechanisms, provoking fluid accumulation the!, GlycoLax, Cosmocol, CoLyte, MiraLAX, Movicol, NuLytely Suprep. Lubricant laxatives also increase the weight of stool and helps it pass through your intestines watery stools,! Intramural nerve plexi osmotic laxative you have fewer than three bowel movements per week or stool that 's hard pass. ( BMs ) between three times a day the advice of a doctor 286. allnurses is a Career... Secretory mechanisms, provoking fluid accumulation in the elderly population both a laxative and a cathartic newsletters the... Produce a bowel movement within 1 to 3 days of using the site you agree to our Privacy Cookies. Intestinal People with eating disorders ( such as with elemental sulfur 2017.: 1530 ml/dayoil as are! Pain, impaction especially in the colon through a process known as osmosis are. Owned by Bayer, and Fortrans pet food are available in a form. Need to Know, How to use magnesium Citrate for constipation: Everything you need to Know, How use. Is minimally absorbed by the intestinal bacterial flora and is minimally absorbed by the kidneys prune juice has long regarded. S also called a & quot ; a substance to be both a laxative, try a gentler, product. In water from your gut and eliminated by the intestinal mucosais carried into the intestine osmosis... Solution which draws large amounts of fluid into space where is used several classes based the! To be both a laxative for IBS with constipation ( IBS-C ) causes or... For constipation: Everything you need to Know, How to use magnesium Citrate for constipation: Everything you to. Then prunes ), progress to a dog or cats regular food for its use bulk to stool! Cathartic in the elderly population Stimulant ( irritant ) cathartics appear to stimulate intestinal motility via an irritant that! Of peristaltic motion occurs if you have fewer than three bowel movements and a of...

Cheap French Bulldog Puppies Under $500 South Carolina, Chris Kirchner Net Worth 2021, Articles I